ABSTRACT
The objectives of this study were to optimize the formula of the self-nanoemulsifying drug delivery system (SNEDDS)containing rosuvastatin and to evaluate its physicochemical characteristics. The solubility and compatibility ofrosuvastatin in surfactants, cosurfactants, and oil excipients were evaluated. The D-optimal experimental design,created by JMP 15 software, was used for analyzing the effects of excipients on the physicochemical characteristicsof SNEDDS to optimize the rosuvastatin SNEDDS formula. The generated nanoemulsions from Ros SNEDDS werecharacterized for droplet size, polydispersity index, and entrapment efficiency. As a result, Cremophor RH40, Capryol90, and PEG 400 were selected to develop the pseudoternary phase diagram to identify the area capable of selfforming nanoemulsion. As the percentage of rosuvastatin calcium increased from 8% to 12%, the area for optimizingthe formula of Ros SNEDDS decreased. The Ros SNEDDS prepared according to predicted formulas possessed selfemulsification to form nanoemulsion with average droplet size less than 100 nm, polydispersity index less than 0.3,and rosuvastatin entrapment higher than 90%.
ABSTRACT
The oral Bio-availability of two different capsule formulations of artmisinin was carried out in six rabbits divided in two groups and seven healthy male volunteers in a single-dose crossover design with randomization for dosing sequence. The experimental results showed that the relative bioavailability of the formulation, that was made of artemisinin solid dispersion system using Eudragit L100 as a carrier on ratio 1:1, was more two times higher than the modification of artemisinin capsules without any modifications. There was a good correlation between in vitro dissolution data obtained by dissolution test with the mean AUG values of each studied group after oral administration.